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However, their growth rates were apparently slower than wt strain (data not shown)

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Therefore, understanding the relationship between the UPS and ferroptosis can help understand the complex mechanism of ferroptosis and provide new strategies for treating human diseases, including tumors (Chen et al., 2021), neurodegenerative diseases (Masaldan et al., 2019), cardiomyopathy (Fang et al., 2019) ischemia-reperfusion injury (Li et al., 2020), stroke (Alim et al., 2019), traumatic brain injury of cerebral hemorrhage (Bao et al., 2021), ageing (Timmers et al., 2020), atherosclerosis (Ouyang et al., 2021), liver injury (Chen et al., 2022), and kidney injury (Tonnus et al., 2021), or related pathological cell death

ARPE-19 cells were used for experimentation from passage 3 through 25