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If the skin feels tight against bone (common directly over the kneecap), move 2-3 cm laterally until you can pinch a fold
In such cases, intramuscular injections may be a better choice
[Crossref] Fuhler GM, Knol GJ, Drayer AL, Vellenga E (2005) Impaired interleukin-8- and GROalpha-induced phosphorylation of extracellular signal-regulated kinase result in decreased migration of neutrophils from patients with myelodysplasia
It depends on your mixing ratio
Simple itching without spreading redness, hives, or swelling beyond a small area (typically under 2 inches) is almost always a minor local reaction
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