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For most patients, the first dose is administered in the week preceding further therapy, with follow-ups every few weeks to help alleviate symptoms and support better health outcomes

However some people may have symptoms of vitamin B12 deficiency despite normal vitamin B12 blood test results, or may have low blood levels despite having no symptoms

That was the idea devised by Australian biochemist Frank Ng his colleagues of Monash University in the 90s

Because B12 is water-soluble, your body uses what it needs and passes most of the excess, and there is no established upper intake limit because harmful effects from high intake have not been well documented