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doi:10.3390/children9010038

2 The APA article notes that many patients discontinue treatment within a year because of side effects, cost, access issues, or other challenges, but this source does not establish mental distress as a uniform or primary reason across all patients

The most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, constipation, and abdominal pain, which typically diminish over time as the body adjusts to the medication

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VSMC phenotypic switching is characterized by transformation from a quiescent contractile to an activated synthetic phenotype, promoting proliferation and leading to the formation of the neointima, the pathological vascular compartment critical for the development of atherosclerosis