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A 2022 review article explains that, although users often claim they work, the benefits may be temporary and could even cause long-term cognitive decline, reduced learning ability, or addiction

Recently, Wang Yongxiang and colleagues provided the first evidence that activation of microglial glucagon-like peptide-1 receptor (GLP-1R) in the spinal cord specifically suppresses neuropathic pain, cancer pain, and diabetic hypersensitivity [20]

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[] A sub-study of the LEAN trial identified several potential mechanisms for liraglutides benefits, including reductions in free fatty acids concentration, peripheral lipolysis, hepatic de novo lipogenesis, hepatic glucose production, and pro-inflammatory cytokines associated with fibrosis

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