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Otherwise, S1P can enter the irreversible catabolic pathway of ceramides using S1P lyase, which cleaves the molecule into an ethanolamine phosphate and a fatty aldehyde (hexadecenal), which in turn could be further metabolized to enter the energetic lipid metabolism (42)

SUMMIT was the most recent trial investigating cardiovascular outcomes of tirzepatide in patients with obesity and heart failure with preserved ejection fraction (HFpEF)

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