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Hong S-Y, Gil H-W, Yang J-O, et al
Notably, the ongoing phase I/II trial of XNW5004, an EZH2 inhibitor, in combination with pembrolizumab (NCT06022757) exemplifies the effort to reprogram epigenetic states and restore ICB sensitivity in solid tumors resistant to conventional treatments
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Weight loss does slow after 6-12 months, but this is because you weigh less and need fewer calories, not because the medication stops working
Future development of ion regulators should focus on organ/cell specificity and targeting
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