fda drug shortages tirzepatide zepbound shortage status 2025 More than a year after the declared the over, Americans are still buying compounded versions of weight-loss drugs like Ozempic and Zepbound, according to a new study in JAMA Health Compounded Semaglutide & Tirzepatide 2025:

Both formats contain the same active ingredient semaglutide and produce similar results

Mounjaro (tirzepatide) weight loss data The SURMOUNT program included multiple phase 3 trials evaluating tirzepatide for weight loss across diverse patient populations

Spacing doses unevenly, such as five days one week and nine days the next, creates peaks and valleys that increase side effects and reduce efficacy

Participants lost about 2% of their body weight in the first month

The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain