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Flow chart of cryo-EM data processing of the hGLP-1rGLP-1RG s complex, including particle projection selection, classification and 3D density map reconstruction, related to Fig

Over the following weeks most people notice subtle metabolic shifts and reduced bloating first (weeks 12), then more noticeable body-composition change around the midsection (weeks 24), then visible fat loss with muscle preserved (weeks 48), with the best results from week 8 onward, diet and exercise still do the heavy lifting

(Phase 2 anchor trial: 24.2% body weight loss at 48 weeks on 12mg, n=338, dose-response across 1mg/4mg/8mg/12mg arms.) Eli Lilly and Company

While gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) affect many patients initially, severe or persistent symptoms may necessitate dose adjustment, temporary dose reduction, or consideration of alternative therapies

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