Based on the working hypothesis of P-gp-dependent collateral sensitivity [14,15,16,17], we examined the ability of tamoxifen as a collateral sensitivity drug for two reasons: a) tamoxifen has been previously shown to activate P-gp ATPase at clinically achievable concentration (46 M) [20, 21], and b) tamoxifen is widely used in the treatment of estrogen receptor-positive breast cancer [22]
Senotherapeutics are a broad class of therapeutic strategies aimed at targeting excess senescent cells and/or the SASP [179]
Its adverse effects are well documented, and DEET has been shown to have cytotoxic and apoptotic properties in nucleated cells
health panels move tremendously frustrating: expert Timothy Caulfield, a health law expert, said the FDA advisory panels decision is tremendously frustrating. I certainly hope that it doesnt influence what Health Canada does
Additionally, SASP inhibits the amino acid transporter xCT, which reduced intracellular GSH levels, diminishes cellular antioxidant defense and induces ferroptosis in cancer cells (74)