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3.3 ApoE and synaptic dysfunction and neuroinflammation Synaptic dysfunction represents an early pathological hallmark of AD, preceding neurodegeneration and memory impairment, thereby culminating in cognitive decline and subsequent memory loss (Tzioras et al., 2023)
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DSIP was first characterized by Marcel Monnier and colleagues at the University of Basel, Switzerland, arising from a series of cross-circulation experiments in which blood from a sleeping rabbit was transferred to an awake recipient, causing measurable changes in the recipient's EEG brainwave patterns consistent with delta-wave sleep induction
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