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This observed risk profile likely stems from two pharmacological factors: (1) the contraindication of metformin in patients with renal insufficiency, and (2) the potential dehydrating effects associated with GLP-1 receptor agonists
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It occurs naturally in your blood plasma, and your body produces less of it as you age, dropping from roughly 200 ng/mL at age 20 to about 80 ng/mL by age 60
Among women with PCOS, semaglutide or tirzepatide prescribing increased from 2.4% in 2021 to 17.6% in 2025, a more than 7-fold increase
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