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Abbasinejad approaches weight loss through a holistic, whole-person lens rather than a one-size-fits-all protocol
The evidence sits with the molecules: STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)
When you eat a meal, your intestinal L-cells release native GLP-1, which binds to receptors in the hypothalamus (reducing appetite), the pancreas (stimulating insulin secretion), and the stomach (slowing gastric emptying)
NICE guidance (NG238) recommends that adults with a 10-year cardiovascular risk of 10% or greater should be offered statin therapy, typically atorvastatin 20 mg daily as first-line treatment
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