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With NNMT blocked, nicotinamide stays in the cell, NAD+ levels climb, and fat cells start burning more fuel instead of storing it
However there is a specific issue for women who are taking tirzepatide and who are relying on oral contraception to prevent pregnancy
The recommendation: take calcium citrate (not calcium carbonate) if you're on a PPI, as citrate doesn't require acid for absorption
If 7.5 mg is working and you feel good, there is no clinical mandate to keep escalating
As with any prescription medication, the best way to figure out which option is right for you is to talk to a licensed provider who can look at your full health picture
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