semaglutide cardiovascular outcomes trial Projected impact of oral on over Wegovy®▽ (semaglutide injection) for cardiovascular

Cag + tirz is the middle option: stronger incretin coverage than CagriSema, plus one approved component

Naturally aged 75-week-old mice treated with PTC-2105 (SC injection, 3.3 mg/kg, 3X/week, n = 5 per cohort) for 15 weeks and subjected to DEXA scan showed an increase in lean mass percentage and a reduction in fat mass percentage , relative to saline-treated mice, restoring body composition and muscle mass closer to that of young mice (12-week-old) The increase in lean mass percentage was confirmed by weighing the gastrocnemius muscles bilaterally at end of study necropsy PTC-2105 is now given SC once weekly with similar results

The picture is not purely negative

But hey, you knowyou cant fish all the time, Bill

PMID: 23 JiangBBaoLHeSChenXJinZYeY