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High-dose or prolonged pyridoxine supplementation can also lead to alterations in other nutrient levels, for example, extended use of large doses has been associated with reduced serum folate concentrations in some reports, which suggests a need to monitor nutritional balance during long-term therapy

FDA has also published safety and quality concerns about compounded AOD-9604

However, those who are consistent with the treatment will tell you at a 3-month visit that they are feeling totally different