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The minimum would be an experiment in which the combination and each component alone were run in the same model, in the same session, with a vehicle arm, and in which the composition of the mixture was analytically confirmed
Because bioavailability via nasal route is unmeasured, any spray dose listed in community protocols is a guess about effective exposure
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Prepared solution: Stability depends on concentration, pH, diluent, sterility, container, preservatives, and temperature
Activity associated with individual subunits of pig heart NAD-specific isocitrate [PMID: 7159097] Laboratory literature summary: Activity associated with individual subunits of pig heart NAD-specific isocitrate dehydrogenase
