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But the portion and preparation method matter
The results were similar for third-line treatment, with the ICER for oral semaglutide 14 mg remaining below $50,000 per QALY in all scenarios except when the trigger for intensification threshold was set at 8.5% instead of 8% ($61,848 per QALY), and the intensification trigger was set to 5 years ($107,040 per QALY)
Nine patients died
Retatrutide enhances glucose-dependent insulin secretion, suppresses glucagon when glucose is elevated, increases energy expenditure, delays gastric emptying, and significantly reduces appetite
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