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European Medicines Agency Decision P/0336/2024 Paediatric Investigation Plan for Retatrutide
Just as hypertension is rarely managed optimally with a single mechanism of action, complex metabolic dysfunction requires a multi-targeted approach
The peptide influences vasomotor tone through the Src-caveolin-1-eNOS pathway, affecting both vasoconstriction and vasodilation depending on baseline vascular state
However, clinical trials on people have not been published to confirm this effect
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