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Its primary functions include: Enhancing Insulin Secretion : GLP-1 increases insulin secretion in a glucose-dependent manner, meaning it only works when blood sugar levels are elevated

Declining estrogen shifts fat storage toward the midsection, reduces muscle protein synthesis, and accelerates bone turnover

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Evidence Trials investigating the use of GLP-1 RAs currently approved in the United States in addition to basal insulin versus an active comparator of prandial insulin are summarized in TABLE 2