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Notably, efferocytosis of eryptotic cells was associated with downregulation of proinflammatory cytokines and upregulation of antiinflammatory and antioxidant factors, including heme oxygenase 1 [241]
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In skeletal muscle, AKT phosphorylation activates mTORC1, increasing ribosomal protein S6 kinase activity and protein translational efficiency the primary molecular mechanism underlying the hypertrophic stimulus
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