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GLP-1s Are Already Used by More People with AUD Than Legacy SUD Treatments Crucially, GLP-1s already have an established history of use in patients with substance use disorders, simply because such a large percentage of the population is taking a GLP-1 for other conditions
These medicines are prescribed in clinical care to support weight management and metabolic health for people living with obesity or related conditions
For instance, Express Scripts and Blue Cross Blue Shield of Michigan have introduced new guidelines that include: Higher BMI Thresholds and Multiple Comorbidities : Express Scripts now requires a BMI of 32 or higher, or a BMI of 27 with documentation of two comorbid conditions
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However, comparisons between short and long term exposure of GLP-1R agonists in the presence of the GLP-1R antagonist Exendin-9, on neurite outgrowth, neuronal sensitivity and TRPV1 expression in thoracic and lumbosacral DRG are required, and will be the focus of future studies
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