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2 (download XLSX Source data for Extended Data Fig

[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%

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Higher purity raw materials Producing stable SAG requires pharmaceutical-grade inputs

FDA Staff Proposal FDA concluded that the balance of physicochemical, historical-use, effectiveness and safety criteria weighed against adding Epitalon free base or Epitalon acetate to the 503A Bulks List