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More importantly, chronic administration of these direct blockers leads to up-regulation of DAT expression [12, 13], which possibly underlie the increased risk for subsequent substance use disorders [14, 15]

17 Currently available GLP-1 RAs can be divided generally into 2 main categories on the basis of their pharmacokinetics: short- and long-acting agents

Consistent use of broad-spectrum sunscreen remains crucial, as continued sun exposure can counteract the benefits of any skin-brightening treatment

Health Canada has not evaluated these compounds for safety or efficacy in treating any medical condition

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