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Orthotopic liver injection model was employed to investigate the tumor growth, progression and stemness gene expression, Briefly, 1 10 6 luciferase-labelled MHCC-97L cells were injected into the left lobes of livers of nude mice, whereas 3 10 6 luciferase-labelled mouse hepatoma Hepa1-6 cells were injected into left lobes of livers of C57BL/6 mice

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Elevated estrogen levels upregulate MSH levels, leading to an increase in melanin production that can cause age spots

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