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Langhorne, P
In this review, for amyloid and tau pathologies, outcomes varied: polyphenolic extract from PEBG (500 or 2500 mg/kg, p.o., for 4 months) had no impact on proteins such as beta-secretase 1 and metalloproteinase domain 10 [21], while quercetin (80 mg/kg, p.o., for 21 days or 16 weeks) lowered cathepsin B and tau phosphorylation [35, 39]
The restoration of transcription levels of earlier hypermethylated genes (mentioned in Table 2) can be correlated to a decrease in methylation levels (Sundaram et al., 2019)
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