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The benefits of semaglutide in obese HFpEF patients were established in the landmark STEP HFpEF trial
Participants were classified as general compliant if they responded always or very often to question 1 of the questionnaires
Importantly, Retatrutide's unique triple receptor agonismtargeting GLP-1, GIP, and glucagon receptorsappears well-tolerated, with adverse events largely consistent with known effects from the broader GLP-1 class, primarily mild gastrointestinal symptoms such as nausea, decreased appetite, and occasional diarrhea, typically resolving within a few weeks of initiation
Providers must evaluate each patient individually
First of all, GLP-1 affects human hunger, appetite, and energy intake reducing even the energy quantity
