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A lower initial proportion of product (UA) to precursor (guanine) measured at baseline was associated with greater improvement in clinical functioning 1 month later ( Figure 4 )

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The aggregated peptides precipitate out of solution as visible particulates or remain suspended as invisible microaggregates that cannot cross biological membranes

To overcome these limitations, there is a need for the development of anticancer agents that can therapeutically intervene in hypoxic cancer cells

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