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Common GLP-1 agonists include: Semaglutide (Ozempic, Wegovy) Liraglutide (Victoza, Saxenda) Dulaglutide (Trulicity) Tirzepatide (Zepbound) While initially used for diabetes management, studies showed that GLP-1 agonists also contribute significantly to weight loss, leading to their approval for obesity treatment as well

Liraglutide showed greater reduction systolic blood pressure over diastolic in a 14 week study systolic blood pressure decreased by -5.2 mm Hg to -7.2 mm Hg compared to placebo with no difference in diastolic blood pressure

You may remember that Avandia was actually pulled from the market because of increased heart failure risk, and that this led to a revolution in diabetes care prioritizing cardiovascular safety before diabetes drugs could be FDA approved