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Animal research suggests several converging mechanisms: modulation of the nitric oxide pathway , upregulation of VEGF driving angiogenesis, interaction with the growth-hormone-receptor pathway , and modulation of inflammatory cytokines including TNF- and IL-6

For instance, the majority (58%) of mouse microbiome studies published in 20182019 did not report the number of mice per cage, and less than 20% of studies reported using singly-housed animals 64

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However, until regulatory bodies and robust human clinical trials catch up to the science, it remains a heavily debated therapy

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