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Skin Pharmacol Physiol
Panels A and B show the severity grades of eosinophils and lymphocytes based on H&E staining, while panels C through H illustrate IRS scores for markers -SMA, fibronectin, vimentin, E-Cadherin, N-Cadherin, and EpCAM in IF
From an immunological perspective, these associations arise from a breakdown in self-tolerance mediated by overlapping T-cell and B-cell autoreactivity, shared cytokine pathways (e.g., IFN-, IL-18), and common antigen-presenting HLA alleles
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