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461 Primary early-stage tumors and advanced metastatic lesions also exhibit marked differences in tumor heterogeneity, drug resistance, and TME composition

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Antimicrobial choice should be guided by swab results or treated empirically under microbiologist advice because broad-spectrum agents may be required to cover Gram-positive organisms commonly found within the skin microbiota, as well as Gram-negative organisms, including Pseudomonas aeruginosa , at a later stage of the condition [4]

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