![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Alternative dosing regimens of tirzepatide](https://www.researchgate.net/publication/363201315/figure/fig3/AS:11431281082605778@1662084799021/Efficacy-of-tirzepatide-in-phase-2-GPGB-14-and-phase-3-SURPASS-1-to-5-15-19.png)
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In addition, SOD was measured using specific colorimetric assay kits (Arbor Assays Company, 1514 Eisenhower Place Ann Arbor, Michigan 48108 USA, Catalog Number K028-H1), while GPx was measured using particular colorimetric assay kits (BioAssay Systems Company, Hayward, CA 94545, USA, Catalog Number: EGPX-100) following the manufacturers instructions for each test
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Alternative dosing regimens of tirzepatide](https://www.researchgate.net/publication/386320227/figure/fig2/AS:11431281294170225@1733081439535/Alternative-dosing-regimens-of-tirzepatide-decrease-costs-and-maintain-efficacy-Panel-A.png)
Liang X, Ma J, Schatten H, Sun Q
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Alternative dosing regimens of tirzepatide](https://www.researchgate.net/profile/Dimitris-Papamargaritis/publication/372782842/figure/tbl1/AS:11431281178256636@1690848555676/Efficacy-of-tirzepatide-5-10-and-15-mg-in-phase-III-global-clinical-trials-for-type-2_Q320.jpg)
If recent meta-analyses were available, these were reported preferentially
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Alternative dosing regimens of tirzepatide](https://framerusercontent.com/images/ABWRRed3JZlLIPR1kgroMiyiqE.png)
In other words, GLP-1s can help people create the energy deficit that is necessary to lose weight
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Alternative dosing regimens of tirzepatide](https://www.nejm.org/cms/asset/52963c11-ac41-4462-9e24-4c95e167fad6/nejmoa2404881_f1.jpg)
Akkermansia muciniphila , Clostridium butyricum , Roseburia , and Faecalibacterium all strong SCFA producers
![efficacy of tirzepatide in phase 2 (GPGB; [14]) and phase 3 (SURPASS-1 Alternative dosing regimens of tirzepatide](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs13300-024-01660-0/MediaObjects/13300_2024_1660_Fig3_HTML.png)
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