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The secreted phospholipase A 2 enzymes include Groups I through III, V, and IX through XIV phospholipase A 2 (Table 2) and they share common features such as low molecular weight (1315 kDa), a catalytic His-Asp dyad, Ca 2+ bound in the active site, and conserved disulfide bonds ( Fig
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*These findings are based on randomized, placebo-controlled clinical trials
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This dysregulation could impair their production of cytokines such as IL-10 and TGF-, thereby disturbing the immune-tolerant environment at the maternal-fetal interface and triggering local inflammation
