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Additionally, rare deficiencies of glutathione cycle enzymes (gamma-glutamylcysteine ligase, glutathione synthetase, 5-oxoprolinase, and gamma-glutamyl transferase) have all been associated with neuropsychiatric and cognitive impairments, although detailed phenomenological characterization has not been reported
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The cathepsin K inhinitor, odanacatib, inhibits the activity of cathepsin K, leading to reduced bone resorption without affecting the cellular integrity of the osteoclast, which is altered by previously described anti-resorptive agents
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