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Improved HbA1c: GLP-1 drugs consistently reduce HbA1c an important long-term marker of diabetes control often by 11.5%, depending on the agent and dose
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Since brain GLP-1R signaling is to a large extent directly triggered by its peripheral secretion from the intestines via vagal stimulation of the NTS neurons, it seems plausible that proper balance in gut microbiota abundance and diversity can influence action of this peptide in the central nervous system
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Musso, G., Gambino, R., Cassader, M., and Pagano, G
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