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Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin'
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The 4-phosphopantetheine group serves as the acyl carrier portion (ACP) of several lipid biosynthetic enzymes that includes cytosolic fatty acid synthase and the mitochondrial NDUFAB1 encoded protein (NADH:ubiquinone oxidoreductase subunit AB1) which serves as the ACP in mitochondrial fatty acid synthesis
Subramaniam et al., 2014
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