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doi: 10.3389/fragi.2025.1696473 Received 31 August 2025 Revised 28 November 2025 Accepted 04 December 2025 Published 06 January 2026 Volume 6 - 2025 Edited by Marco P Brotto, University of Texas at Arlington, United States Reviewed by Eduardo Abreu, University of MissouriKansas City, United States Andr Luis Shinohara, Faculdade de Odontologia da Universidade de So Paulo, Brazil Updates Copyright 2026 Da Silva Rodrigues, Lopes da Silva, Crystine da Silva Sobrinho, Benjamim, Abud, Ortiz, Cristini de Freitas and Bueno Jnior

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GPX5 is synthesized primarily by epididymal head epithelial cells and secreted into the epididymal cavity to compensate for a deficiency of antioxidant enzymes in immature sperm ( 2 O 2 , and these mice did not exhibit significant defects in the epididymis and sperm cells ( 2 O 2 scavengers was detected ( 2.6 GPX6 Glutathione peroxidase 6 (GPX6), also known as olfactory organ glutathione peroxidase ( It is believed that GPX6 is mainly expressed in embryonic and olfactory organ epithelial cells, and may be involved in the transmission and degradation of odor-related signals

Clinical studies have shown 51% reduction in fine lines & wrinkles in 4 weeks (NIH)