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Aging individuals: Natural DSIP levels decline with age
The BMI cut-off of 35.0 kg/m 2 was used in line with NICE guidance, which recommends considering GLP-1 RAs for people with BMI 35.0 kg/m 2 [6]
After reaching a goal weight, some patients may transition into a maintenance phase, but adjustments are individualized based on response, tolerance, and long-term goals
It was developed by modifying the natural GLP-1 molecule to: Promote albumin binding: This extends circulation time by slowing renal clearance Resist DPP-4 degradation: Structural modifications protect it from the enzyme that breaks down natural GLP-1 Semaglutide selectively binds to and activates the GLP-1 receptor, triggering the same beneficial downstream effects as natural GLP-1but with sustained activity over days rather than minutes
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