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Its a marker, not a mechanism

Headaches and Fatigue: Some users report mild headaches or temporary fatigue during initial supplementation, likely related to detoxification processes and cellular adjustments to enhanced antioxidant capacity

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You should NOT undergo microneedling if you: Additionally, microneedling has not been formally evaluated in patients with certain conditions, including active acne, rosacea, eczema, psoriasis, diabetes, active infections, keloid scarring, or those on blood thinners or immunosuppressive therapy

Always consult a qualified healthcare professional before starting or changing any medical treatment