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Thus, if you have low levels of HCl (known as hypochlorhydria), or if you have low levels of your digestive and/or pancreatic enzymes that target protein, you may not be able to absorb sufficient levels of the amino acids required for glutathione synthesis even if you consume adequate levels
PLoS Biol
Additionally, high cortisol levels have been shown to reduce SAMe levels, which are crucial components of the methylation pathway
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