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The Phase 3 OPTIONS study (536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

Davin8r September 10, 2024, 3:22am #8 Neo: Any sense of this increased baseline insulin levels, thats my worry with GLP-1 as CR mimetic that key longevity pathway (and IGF, etc) might actually go in the wrong direction with these Fasting insulin went down dose-dependently in the retatrutide phase 2 study, for instance (see Table S6): I havent looked at sema or tirz data specifically, but Id imagine its the same

For a dedicated regulatory tracker, see our Retatrutide approval status 2026 article

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