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278,279 In addition, this technology is used in the clinically approved vaccines ALC-0315 (BNT162b2-Comirnaty) and SM-102 (mRNA-1273-Spikevax), where the pKa value ranges from 6.1 to 6.7
demonstrated that erastin-induced ferroptosis elevated lysosome-associated membrane protein 2a (LAMP2a) expression and promoted chaperone-mediated autophagy (CMA) while facilitating GPX4 degradation, suggesting a possible connection between autophagy and ferroptosis (Wu et al., 2019)
This makes them a useful option for clinical studies which might prefer a needle-free delivery system, a nasal spray delivery can also eliminate potential side effects associated with subcutaneous injections
2.4 Exposure definition The primary exposure was GLP-1 RA use, defined as any documented prescription fill for a GLP-1 RA (liraglutide, semaglutide, exenatide, and dulaglutide) at least 90 days prior to the index date, based on prescription records in the electronic health record
W., Charron, G., Hang, H
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