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It is well described that relatively high doses of anti-PCSK9 antibodies, as for instance 140 mg every two weeks of evolocumab, are required to overcome the antigen sink 37,38

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Untreated endocrine disorders including hypothyroidism and uncontrolled diabetes require correction before initiating either compound

It achieves this by reducing oxidative stress and inflammation, as evidenced by decreased levels of inflammatory cytokines and oxidative markers in lung tissues

This contributes to improved metabolic health, even for those without diabetes, and supports overall well-being