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One involves the secretion of cytotoxic granules containing perforin and granzyme, while the other triggers apoptosis through death receptor pathways by expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and/or Fas ligand (FasL)
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Furthermore, in a maize cultivar with symptomless SCMV-resistance, a proteomic analysis revealed a down-regulation of two different GSTs in later phases of virus infection, pointing to a role of GSTs in establishing virus resistance at the early stages of pathogenesis (Wu et al., 2013a,b)
CONCLUSION The potential of these new therapies to effectively treat obesity and T2DM and radically reduce their complications pose a major challenge to the health authorities who will need to decide how these new possibilities should be implemented to the benefit of the people at risk
Pyykk JE, Hinnen C, Aydin , Nieuwdorp M, De Brauw LM, Bruin SC, et al
