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Most patients notice changes within 24 weeks , with continued improvement over several months
Other candidates for dual and triple combination therapies have focused on glucagon receptor agonism with its potential specific added effects on the liver
You may have a deficiency if you are vegan, dont eat enough B12 rich food, or if you have other health conditions which mean you are unable to absorb it properly
The naltrexone component has its own considerations (interactions with opioids, potential liver effects), and stacking it with a GLP-1 hasnt been well studied
Other GLP-1s and related agents Dulaglutide, exenatide and other GLP-1 RAs used primarily for diabetes generally produce modest weight loss compared with the agents above
