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Because of the key sex differences in the effect of ES [240,241,242,243] and nutrition [244] and general metabolisms [245] and disease prevalence and presentation [238, 239], it is key for future studies to consider both sexes when assessing efficacy of nutritional interventions in ES research and to include sex as a discovery variable

In general, the more weight you lose with semaglutide, the greater the improvements you'll see in your overall body composition across all areas.

Careful follow-up is necessary to identify uncommon complications or delayed manifestations

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There is also a long list of associated GLP-1 side effects