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Most gastrointestinal events were classified as mild to moderate, and the majority were transient, resolving within the first several weeks of treatment or after dose stabilization

Participant characteristics Across all trials, participants mean HbA 1c at baseline was 66.47 mmol/mol (8.2%), mean body weight was 91.5 kg and mean age was 58 years (Table 1)

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Initial pre-induction stages utilize compounds like nicotinamide, -mercaptoethanol, and retinoic acid, followed by exposure to high-glucose Dulbeccos Modified Eagle Medium (DMEM) supplemented with growth factors such as activin A, hepatocyte growth factor (HGF), or epidermal growth factor (EGF)

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