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Semaglutide is available as tablets or injections , which are used to treat diabetes or help with weight loss
The cleavage reagent used for the cleavage is TFA, TIS, EDT, PhOH, H 2 Mixed solution of O, volume ratio TFA: and (3) TIS: EDT (electro-thermal transfer coating): PhOH: h 2 O-85-95: 2-5:0-3:0-2:1-5, with a cleavage time of 1.5-3.5 hours
They are highly toxic to the liver and are amongst the major identified risk factors for hepatocellular carcinoma 10,11,12
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