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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]
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A total of 16 healthy male Wistar rats (approximately 200 g) were treated daily with either saline (n=8) or L-carnitine (n=8
Patients should be counselled on gradual dose escalation to minimise these effects
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